Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
Identifieur interne : 001454 ( Main/Exploration ); précédent : 001453; suivant : 001455Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
Auteurs : Krishnan Suresh Kumar [Inde] ; Swastika Ganguly ; Ravichandran Veerasamy ; Erik De ClercqSource :
- European journal of medicinal chemistry [ 1768-3254 ] ; 2010.
Descripteurs français
- KwdFr :
- Antiviraux (), Antiviraux (pharmacologie), Antiviraux (synthèse chimique), Bases de Schiff (), Humains, Lignée cellulaire, Quinazolines (), Quinazolines (pharmacologie), Quinazolines (synthèse chimique), Spectrophotométrie IR, Spectroscopie par résonance magnétique, Évaluation préclinique de médicament.
- MESH :
- pharmacologie : Antiviraux, Quinazolines.
- synthèse chimique : Antiviraux, Quinazolines.
- Antiviraux, Bases de Schiff, Humains, Lignée cellulaire, Quinazolines, Spectrophotométrie IR, Spectroscopie par résonance magnétique, Évaluation préclinique de médicament.
English descriptors
- KwdEn :
- Antiviral Agents (chemical synthesis), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Cell Line, Drug Evaluation, Preclinical, Humans, Magnetic Resonance Spectroscopy, Quinazolines (chemical synthesis), Quinazolines (chemistry), Quinazolines (pharmacology), Schiff Bases (chemistry), Spectrophotometry, Infrared.
- MESH :
- chemical , chemical synthesis : Antiviral Agents, Quinazolines.
- chemical , chemistry : Antiviral Agents, Quinazolines, Schiff Bases.
- chemical , pharmacology : Antiviral Agents, Quinazolines.
- Cell Line, Drug Evaluation, Preclinical, Humans, Magnetic Resonance Spectroscopy, Spectrophotometry, Infrared.
Abstract
A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), vaccinia virus, vesicular stomatitis virus, herpes simplex virus-1 TK- KOS ACVr, para influenza-3 virus, reovirus-1, Sindbis virus, Coxsackie virus B4, Punta Toro virus, feline corona virus (FIPV), feline herpes virus, respiratory syncytial virus, influenza A H1N1 subtype, influenza A H3N2 subtype, and influenza B virus. Compound 2a showed better antiviral activity against the entire tested virus.
DOI: 10.1016/j.ejmech.2010.07.058
PubMed: 20724039
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000D30
- to stream PubMed, to step Curation: 000D30
- to stream PubMed, to step Checkpoint: 000D13
- to stream Ncbi, to step Merge: 000223
- to stream Ncbi, to step Curation: 000223
- to stream Ncbi, to step Checkpoint: 000223
- to stream Main, to step Merge: 001456
- to stream Main, to step Curation: 001454
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.</title><author><name sortKey="Kumar, Krishnan Suresh" sort="Kumar, Krishnan Suresh" uniqKey="Kumar K" first="Krishnan Suresh" last="Kumar">Krishnan Suresh Kumar</name><affiliation wicri:level="1"><nlm:affiliation>Medicinal chemistry research Laboratory, KMCH College of Pharmacy, Coimbatore, India. pharmsuki@gmail.com</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Medicinal chemistry research Laboratory, KMCH College of Pharmacy, Coimbatore</wicri:regionArea><wicri:noRegion>Coimbatore</wicri:noRegion></affiliation></author><author><name sortKey="Ganguly, Swastika" sort="Ganguly, Swastika" uniqKey="Ganguly S" first="Swastika" last="Ganguly">Swastika Ganguly</name></author><author><name sortKey="Veerasamy, Ravichandran" sort="Veerasamy, Ravichandran" uniqKey="Veerasamy R" first="Ravichandran" last="Veerasamy">Ravichandran Veerasamy</name></author><author><name sortKey="De Clercq, Erik" sort="De Clercq, Erik" uniqKey="De Clercq E" first="Erik" last="De Clercq">Erik De Clercq</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20724039</idno><idno type="pmid">20724039</idno><idno type="doi">10.1016/j.ejmech.2010.07.058</idno><idno type="wicri:Area/PubMed/Corpus">000D30</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D30</idno><idno type="wicri:Area/PubMed/Curation">000D30</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D30</idno><idno type="wicri:Area/PubMed/Checkpoint">000D13</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D13</idno><idno type="wicri:Area/Ncbi/Merge">000223</idno><idno type="wicri:Area/Ncbi/Curation">000223</idno><idno type="wicri:Area/Ncbi/Checkpoint">000223</idno><idno type="wicri:Area/Main/Merge">001456</idno><idno type="wicri:Area/Main/Curation">001454</idno><idno type="wicri:Area/Main/Exploration">001454</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.</title><author><name sortKey="Kumar, Krishnan Suresh" sort="Kumar, Krishnan Suresh" uniqKey="Kumar K" first="Krishnan Suresh" last="Kumar">Krishnan Suresh Kumar</name><affiliation wicri:level="1"><nlm:affiliation>Medicinal chemistry research Laboratory, KMCH College of Pharmacy, Coimbatore, India. pharmsuki@gmail.com</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Medicinal chemistry research Laboratory, KMCH College of Pharmacy, Coimbatore</wicri:regionArea><wicri:noRegion>Coimbatore</wicri:noRegion></affiliation></author><author><name sortKey="Ganguly, Swastika" sort="Ganguly, Swastika" uniqKey="Ganguly S" first="Swastika" last="Ganguly">Swastika Ganguly</name></author><author><name sortKey="Veerasamy, Ravichandran" sort="Veerasamy, Ravichandran" uniqKey="Veerasamy R" first="Ravichandran" last="Veerasamy">Ravichandran Veerasamy</name></author><author><name sortKey="De Clercq, Erik" sort="De Clercq, Erik" uniqKey="De Clercq E" first="Erik" last="De Clercq">Erik De Clercq</name></author></analytic><series><title level="j">European journal of medicinal chemistry</title><idno type="eISSN">1768-3254</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (chemical synthesis)</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (pharmacology)</term><term>Cell Line</term><term>Drug Evaluation, Preclinical</term><term>Humans</term><term>Magnetic Resonance Spectroscopy</term><term>Quinazolines (chemical synthesis)</term><term>Quinazolines (chemistry)</term><term>Quinazolines (pharmacology)</term><term>Schiff Bases (chemistry)</term><term>Spectrophotometry, Infrared</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux ()</term><term>Antiviraux (pharmacologie)</term><term>Antiviraux (synthèse chimique)</term><term>Bases de Schiff ()</term><term>Humains</term><term>Lignée cellulaire</term><term>Quinazolines ()</term><term>Quinazolines (pharmacologie)</term><term>Quinazolines (synthèse chimique)</term><term>Spectrophotométrie IR</term><term>Spectroscopie par résonance magnétique</term><term>Évaluation préclinique de médicament</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Antiviral Agents</term><term>Quinazolines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term><term>Quinazolines</term><term>Schiff Bases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Quinazolines</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Quinazolines</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Antiviraux</term><term>Quinazolines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line</term><term>Drug Evaluation, Preclinical</term><term>Humans</term><term>Magnetic Resonance Spectroscopy</term><term>Spectrophotometry, Infrared</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Antiviraux</term><term>Bases de Schiff</term><term>Humains</term><term>Lignée cellulaire</term><term>Quinazolines</term><term>Spectrophotométrie IR</term><term>Spectroscopie par résonance magnétique</term><term>Évaluation préclinique de médicament</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), vaccinia virus, vesicular stomatitis virus, herpes simplex virus-1 TK- KOS ACVr, para influenza-3 virus, reovirus-1, Sindbis virus, Coxsackie virus B4, Punta Toro virus, feline corona virus (FIPV), feline herpes virus, respiratory syncytial virus, influenza A H1N1 subtype, influenza A H3N2 subtype, and influenza B virus. Compound 2a showed better antiviral activity against the entire tested virus.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="De Clercq, Erik" sort="De Clercq, Erik" uniqKey="De Clercq E" first="Erik" last="De Clercq">Erik De Clercq</name><name sortKey="Ganguly, Swastika" sort="Ganguly, Swastika" uniqKey="Ganguly S" first="Swastika" last="Ganguly">Swastika Ganguly</name><name sortKey="Veerasamy, Ravichandran" sort="Veerasamy, Ravichandran" uniqKey="Veerasamy R" first="Ravichandran" last="Veerasamy">Ravichandran Veerasamy</name></noCountry><country name="Inde"><noRegion><name sortKey="Kumar, Krishnan Suresh" sort="Kumar, Krishnan Suresh" uniqKey="Kumar K" first="Krishnan Suresh" last="Kumar">Krishnan Suresh Kumar</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001454 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001454 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:20724039
|texte= Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:20724039" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidV2
| This area was generated with Dilib version V0.6.33. |  |